Dementia generally is not a single disease, instead a name for a group of symptoms that include problems with memory and thinking. Although there is no specific single test for dementia and its cure has failed so far, but there are lots of different types of dementia and Alzheimer’s is said to be the most common and most researched one among them all.

However, a new condition has been found which is age-related TDP-43 encephalopathy is or simply known as Late, shares similar symptoms to Alzheimer but it is a distinct disease on its own. Although both dementias (Alzheimer and Late) can co-exist, there are some striking differences between them. The differences are as follows;

  1. Late appears to affect the “oldest old” especially people over 80 years while Alzheimer affect adults especially from 30 and above.
  2. Unlike Alzheimer’s disease, Late tends to cause a more gradual decline in memory.
  3. Late appears to be linked to the accumulation of a certain protein, TDP-43, in the brain while Alzheimer’s is linked to two other brain proteins known as amyloid and tau.
  4. Treatment trials of drugs that are designed to work against Alzheimer’s will not necessarily have any efficacy against Late.


Leave a Reply

Your email address will not be published. Required fields are marked *